Ahmed Bentridi se mérite un prix lors de la 7e Journée universitaire

2 mars 2019

La 7e Journée Universitaire du Département de radiologie, radio-oncologie et médecine nucléaire de la Faculté de médecine de l’Université de Montréal a eu lieu le 21 février 2019 à l’agora du Centre de recherche du CHUM.  Trois étudiants ont reçu un prix pour leur présentation.

Premier prix – Présentation scientifique par affiche par un étudiant 


Ahmed Bentridi

Titre de la présentation

Safety and efficacy of Midline and Peripherally Inserted Central Catheter for intravenous therapy: a randomized controlled trial – Protocol and preliminary data


Bentridi A, Soulez G, Gilbert P, Giroux MF, Bouchard L, Perreault P, Oliva VL, Chouinard A, Bernier P, Therasse E


Radiologie, CHUM; Université de Montréal


Purpose. To test the hypothesis that Midlines are non-inferior to PICC for intravenous therapy that do not require a central catheter.

Materials and Methods. Prospective randomized open-label clinical trial, in which Midlines are compared to PICCs in adults who required peripheral intravenous therapy of 1-4 weeks. With a noninferiority margin of 10%, 510 patients need to be enrolled in this study. Patients eligible for Midline according to recommendations of the Infusion Nurses Society (2016) were included. Vesicant intravenous therapy were excluded. Patients were followed until one week after venous access removal.  The primary efficacy outcome was the percentage of patients who completed their treatment without limitation due to catheter dysfunction.

Results. This interim analysis includes the first 72 patients enrolled (45 men, 27 women; average age: 52,6 years) since August 2018, 35 randomized to the Midline group and 37 to the PICC group.  One catheter was removed prematurely in both groups (P=0,78). Catheter dysfunction, mostly incapacity to draw blood, was observed in 6/35 (21%) patients in the Midline group versus 1/36 (2,8%) patients in the PICCs group (p=0,01). There were 3/35 (8,5%) device related adverse events in midline group and no adverse event in PICCs (p=0,46), There was one unrelated death in the PICC group and no major device related event in both groups.

Conclusion.  Comparison of primary efficacy outcome with available data is not yet conclusive. However, given the greater catheter dysfunction rate with Midlines, these catheters should not replace PICC in patients with difficult venipuncture and who require blood samplings.